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Disseminated Candidiasis

Imaging findings

Chest CT shows numerous tiny, sub-centimeter nodules in a miliary distribution throughout both lungs, with some located in the subpleural regions and along the fissures. Biopsy of coexisting skin lesions demonstrated yeast-like organisms consistent with disseminated Candida glabrata infection.

Key takeaways

Miliary lung nodules in an immunocompromised or neutropenic patient typically represent blood-borne hematogenous dissemination. While tuberculosis and histoplasmosis are common causes, disseminated Candida (especially Candida glabrata) must be considered, particularly when accompanied by characteristic skin lesions.

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