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Smoking-Related Cystic Lung Disease with DIP-Like Ground-Glass Opacity

Imaging findings

A smoker's chest radiograph shows only subtle reticular attenuation suggesting cystic disease, but thin-section CT obtained the following month shows extensive cystic disease throughout both lungs with ground-glass attenuation extending to the lower zones, consistent with a heavy burden of smoker's macrophages, plus a few small well-circumscribed cystic spaces at the left base.

Key takeaways

Extensive cystic change with background ground-glass opacity in a smoker represents the spectrum of smoking-related lung disease -- including smoker's macrophage accumulation and desquamative-interstitial-pneumonia-like ground glass -- and the chest radiograph substantially underestimates the degree of parenchymal involvement seen on CT.

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