CTICasesDesquamative Interstitial Pneumonia
Imaging findings
Serial CT chest scans over 3 years show stable, diffuse ground-glass opacities, mild basilar septal thickening, and small, well-defined cystic spaces in the lower lobes. Surgical lung biopsy confirmed desquamative interstitial pneumonia (DIP), showing a massive accumulation of intra-alveolar pigmented macrophages (smoker's macrophages).
Key takeaways
Desquamative interstitial pneumonia (DIP) is a smoking-related interstitial lung disease characterized by the diffuse accumulation of macrophages within alveolar spaces. Radiographically, it presents with diffuse or basal-predominant ground-glass opacities and small cysts. While clinically progressive if smoking continues, it carries a better prognosis than UIP and responds well to smoking cessation and corticosteroids.
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