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Stage-Stage NSIP with Transient PA filling defects

Imaging findings

CT angiography shows smoke-like filling defects in the lobar pulmonary arteries with slow blood flow, associated with severe lower-lobe-predominant NSIP-like fibrosis and pulmonary hypertension, which was twice misdiagnosed as acute PE.

Key takeaways

In patients with severe end-stage interstitial lung disease, increased pulmonary vascular resistance leads to sluggish flow in the lower lobe pulmonary arteries. On CT angiography, this slow flow can manifest as transient, poorly-defined filling defects (smoke/mixing artifact) that mimic pulmonary embolism.

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