CTICasesNivolumab-Induced Pneumonitis
Imaging findings
Serial CT chest scans in a patient receiving Nivolumab show the progression of ground-glass opacities into organizing pneumonia characterized by bilateral consolidations and reverse halo signs (atoll sign), resolving with residual peribronchovascular fibrosis.
Key takeaways
Immune checkpoint inhibitors like Nivolumab can cause drug-induced pneumonitis. The most common radiographic pattern is organizing pneumonia (characterized by peripheral/peribronchial consolidations and reverse halo signs) or NSIP. This can progress to chronic, residual peri-bronchovascular fibrosis.
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