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Strongyloides Hyperinfection Syndrome

Strongyloides Hyperinfection Syndrome▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

Chest CT demonstrates diffuse ground-glass opacities and denser consolidation with a prominent dependent distribution, accompanied by bilateral pleural effusions and a fine micronodular component. Bronchoalveolar lavage (BAL) and stool cultures recovered Strongyloides stercoralis larvae on a background of abundant red blood cells, reflecting diffuse alveolar hemorrhage.

Key takeaways

Strongyloides stercoralis can persist asymptomatically in the host for decades and cause life-threatening hyperinfection syndrome when the patient becomes immunocompromised, such as in advanced HIV/AIDS. The pulmonary phase of hyperinfection is associated with severe alveolar hemorrhage, which characteristically presents as dependent-predominant dense consolidations due to the gravity-dependent settling of blood.

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