CTICasesCystic Lung Disease in Chronic Lymphocytic Leukemia
Imaging findings
CT chest shows numerous thin-walled, well-circumscribed lung cysts, some containing internal septations and tiny residual tissue elements. The patient had a history of chronic lymphocytic leukemia (CLL) and progressive dyspnea, and biopsy confirmed amyloid-like light chain protein deposition forming these cysts.
Key takeaways
Unusual cystic lung disease can be a rare manifestation of lymphoproliferative disorders like CLL. It is typically mediated by localized light chain deposition (amyloidosis or light chain deposition disease), which causes alveolar wall destruction and subsequent cyst formation.
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