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Mediastinal Lipomatosis

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Imaging findings

Chest radiography demonstrates a large anterior mediastinal mass with a positive hilum overlay sign. Chest CT shows a massive, low-attenuation fat-containing mass in the anterior mediastinum causing severe compressive atelectasis of the adjacent lungs, with focus areas of higher-attenuation, complex soft tissue representing necrosis.

Key takeaways

Mediastinal lipomatosis is a benign proliferation of fat that can occasionally mimic a lipomatous tumor. When a fat-dominant mediastinal mass is exceedingly large, causes significant mass effect, or contains thick septations, nodular non-fatty components, or necrosis, histographical evaluation is required to rule out well-differentiated liposarcoma or liposarcomatous transformation.

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