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Fentanyl Patch Inhalation Lung Injury

Imaging findings

Chest radiographs and CT in a patient with acute respiratory distress show bilateral, symmetric, diffuse ground-glass opacities with geographic sparing, primarily in a perihilar distribution, consistent with acute alveolar hemorrhage or non-cardiogenic pulmonary edema.

Key takeaways

Inhaling or smoking illicit substances, including fentanyl patches, can cause acute toxic lung injury (similar to "crack lung"). This typically manifests as acute diffuse alveolar damage, capillary leak, and alveolar hemorrhage, presenting radiographically with diffuse ground-glass opacities and clinically with hemoptysis and acute respiratory distress.

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