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Undifferentiated pleomorphic sarcoma of the mediastinum

Imaging findings

CT shows a massive, coarsely calcified, necrotic mediastinal and pericardial mass encasing the IVC and displacing the heart, with associated mediastinal lymphadenopathy. Biopsy confirmed undifferentiated pleomorphic sarcoma.

Key takeaways

Primary mediastinal sarcomas are rare, highly aggressive tumors that can grow to massive sizes. They often present with extensive necrosis, calcification, and compression of vital structures such as the IVC, and carry a poor prognosis.

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