CTICasesMiliary metastases from EGFR-mutant lung adenocarcinoma
Imaging findings
CT scan of a female never-smoker shows a right upper lobe lung mass, mediastinal lymphadenopathy, a pleural effusion, and diffuse, tiny miliary lung nodules. Follow-up CT shows complete clearance of the nodules and mass after EGFR inhibitor therapy.
Key takeaways
Lung adenocarcinoma in never-smokers (often EGFR-mutated) can present with diffuse, tiny miliary-like nodules and pleural disease. These tumors show an exceptional, rapid response to targeted tyrosine kinase inhibitors (such as osimertinib).
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