CTICasesMediastinal Gray Zone Lymphoma
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Imaging findings
Contrast-enhanced CT and FDG-PET/CT demonstrate a massive, highly necrotic, and aggressively infiltrative anterior mediastinal mass. The mass extends directly into the anterior chest wall soft tissues and exhibits intense, heterogeneous FDG-avidity throughout.
Key takeaways
Gray zone lymphoma is an aggressive, rare lymphoma subtype with clinical and pathological features intermediate between primary mediastinal large B-cell lymphoma and classical Hodgkin lymphoma. It classically presents in young adults as a large, infiltrative, and necrotic anterior mediastinal mass that carries a poorer prognosis than classical Hodgkin lymphoma.
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