CTICasesLymphocytic Interstitial Pneumonia Associated with T-Cell Large Granular Lymphocyte Leukemia
Imaging findings
Chest CT shows several thin-walled, perivascular cysts, with the largest located in the left lung base, in a patient with a monoclonal gammopathy and a kappa-predominant plasma cell population. Bone marrow biopsy confirmed T-cell large granular lymphocyte (LGL) leukemia.
Key takeaways
Perivascular lung cysts on CT are highly characteristic of the lymphocytic interstitial pneumonia (LIP) and light chain deposition disease (LCDD) spectrum. These findings can be seen in monoclonal gammopathies and lymphoproliferative disorders like T-cell LGL leukemia, where abnormal protein deposition triggers macrophage activation, leading to localized tissue destruction and cyst formation.
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