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Ossified pleural metastases from osteosarcoma

Imaging findings

Serial CT scans in a 23-year-old female with a history of jaw osteosarcoma show progressive development of multiple ossified, plaque-like pleural masses along the mediastinal and costal pleural surfaces, simulating benign pleural plaques.

Key takeaways

Osteosarcoma has a propensity to metastasize to the lungs and pleural space. Pleural metastases from osteosarcoma are typically ossified (producing osteoid matrix) and can mimic calcified asbestos-related pleural plaques or mesothelioma on CT.

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