CTICasesPhosphaturic mesenchymal tumor causing tumor-induced osteomalacia
Imaging findings
CT shows a hypervascular posterior mediastinal paraspinal mass, alongside multiple non-traumatic, healing insufficiency fractures of the pelvis, scapula, ribs, and femur. Postoperatively, the patient developed transient 'hungry bone syndrome'.
Key takeaways
Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome caused by phosphaturic mesenchymal tumors that secrete FGF-23, leading to renal phosphate wasting and severe osteomalacia. Resection of these hypervascular tumors is curative but can trigger hungry bone syndrome postoperatively.
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