CTICasesGranulomatous-Lymphocytic Interstitial Lung Disease (GLILD)
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Imaging findings
Chest CT reveals multiple solid and ground-glass pulmonary nodules centered around the airways and bronchovascular bundles, showing interval enlargement over time with internal air bronchograms, accompanied by reactive lymphadenopathy and mild splenomegaly.
Key takeaways
Granulomatous-lymphocytic interstitial lung disease (GLILD) is a rare, non-infectious pulmonary complication of common variable immunodeficiency (CVID) characterized by a mixture of granulomatous and lymphoproliferative histopathology. The imaging combination of persistent or expanding bronchocentric nodules, splenomegaly, and lymphadenopathy in a patient with CVID should prompt consideration of GLILD, which is associated with a worse prognosis and may progress to pulmonary fibrosis.
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