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Diffuse Panbronchiolitis

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Imaging findings

High-resolution CT shows hyperinflated lungs with widespread centrilobular nodules, tree-in-bud opacities, bronchocentric nodularity, and bronchiectasis. These findings are most severe within the right middle lobe and lingula.

Key takeaways

Diffuse panbronchiolitis is a chronic, progressive inflammatory airway disease that primarily affects the respiratory bronchioles. While classically described in East Asian populations, it can be encountered in non-Asian patients and is characterized by a strong association with chronic sinusitis and a dramatic therapeutic response to long-term, low-dose macrolide therapy.

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