CTICasesAPL Differentiation Syndrome
Imaging findings
CT in an acute promyelocytic leukemia (APL) patient shows diffuse, extensive crazy-paving ground-glass opacities and consolidations with pleural effusions two days after starting ATRA and arsenic trioxide therapy, representing differentiation syndrome.
Key takeaways
Differentiation syndrome (formerly ATRA syndrome) is a life-threatening complication of APL therapy. It is characterized by cytokine release causing increased capillary permeability and pulmonary edema. Prompt treatment with high-dose steroids is mandatory.
AI-assisted summary — may contain errors. Verify against the source video. Learn more
More from this webinar
- Granulomatosis with Polyangiitis with Superimposed COVID-19Infection
- Antisynthetase Syndrome mimicking COVID-19ILD
- Misregistration Artifact mimicking Anomalous Right Coronary ArteryArtifact
- Extramedullary Hematopoiesis in MyelofibrosisVascular
- Plexiform Arteriopathy in Pulmonary HypertensionVascular
- Cryoablation-Induced Pulmonary Vein StenosisIatrogenic
- Rapidly Progressive Silicosis in a Countertop WorkerExposure
- Silicosis with Galaxy Sign and PseudoplaquesExposure
See all cases from August 8, 2020 →