Antisynthetase Syndrome mimicking COVID-19
Imaging findings
Chest CT shows patchy, basilar-predominant ground-glass opacities, consolidations, and architectural distortion. Comparison with scans from two years prior shows chronic, slowly progressive fibrotic NSIP/OP overlap pattern, confirming antisynthetase syndrome rather than acute COVID-19.
Key takeaways
Chronic interstitial lung diseases, particularly antisynthetase syndrome-associated NSIP/OP, can closely mimic the peripheral ground-glass and consolidative patterns of acute viral pneumonias like COVID-19. Reviewing prior imaging is critical to avoid unnecessary quarantine or treatment.
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