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Plexiform Arteriopathy in Pulmonary Hypertension

Imaging findings

CT in a patient with treated Group 1 PAH shows central pulmonary artery dilatation, pleural effusions, hilar/mediastinal adenopathy, and tiny centrilobular ground-glass nodules representing plexiform arteriopathy rather than PVOD/PCH, in the setting of severe hypoalbuminemia.

Key takeaways

Tiny centrilobular ground-glass nodules in Group 1 pulmonary arterial hypertension represent plexiform lesions (arteriopathy). When associated with pleural effusions and adenopathy, this can raise concern for PVOD, but low oncotic pressure (hypoalbuminemia) must be excluded.

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