CTICasesExtramedullary Hematopoiesis in Myelofibrosis
Imaging findings
Chest CT demonstrates diffuse, marked osteosclerosis of the spine and ribs, massive splenomegaly, and lobulated bilateral paravertebral soft tissue masses in the posterior mediastinum, consistent with extramedullary hematopoiesis.
Key takeaways
Myelofibrosis leads to bone marrow replacement, forcing hematopoiesis to occur in extramedullary sites. The posterior mediastinum/paravertebral regions are classic locations for these vascular, benign masses, which should not be confused with neurogenic tumors or metastases.
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