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Mediastinal Epithelioid Hemangioendothelioma

Mediastinal Epithelioid Hemangioendothelioma▶ Watch on YouTube — age-restricted, cannot embed here

Imaging findings

CT angiography shows a soft tissue mediastinal mass causing focal narrowing of the left brachiocephalic vein, with minor calcification. Histopathology from core biopsy and final resection demonstrates an epithelioid hemangioendothelioma staining positive for CD34.

Key takeaways

Epithelioid hemangioendothelioma is a rare vascular neoplasm of intermediate malignant potential that can arise in the mediastinum, pleura, or lungs. It can mimic lung cancer or other mediastinal masses, staining positive for endothelial markers like CD34, and carries a significant risk of local recurrence or distant metastasis.

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