CTICasesLight Chain Deposition Disease
Imaging findings
High-resolution chest CT demonstrates multiple circumscribed, perivascular cysts distributed along the bronchovascular bundles. There is a relative absence of nodules, parenchymal consolidation, or airway wall thickening.
Key takeaways
Light chain deposition disease (LCDD) and pulmonary amyloidosis are rare plasma cell dyscrasias that can manifest in the lung as perivascular cysts, mimicking lymphocytic interstitial pneumonia (LIP), Birt-Hogg-Dubé syndrome, or lymphangioleiomyomatosis (LAM). The presence of multiple myeloma (especially kappa light-chain type) strongly points toward LCDD/amyloidosis as the underlying cause of these cystic changes.
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