CTICasesEarly Metastatic Pulmonary Calcification
Imaging findings
Baseline chest CT demonstrates a very subtle area of ground-glass opacity in the left upper lobe. A follow-up CT one year later shows progression to a larger, more confluent area of ground-glass opacity with a central, solid, highly dense nodule. Core needle biopsy of the lesion revealed nodular pulmonary ossification and fibrosis without malignant cells.
Key takeaways
Metastatic pulmonary calcification in patients with chronic renal failure and abnormal calcium-phosphate product can initially present as focal, non-calcified ground-glass opacities that mimic early adenocarcinoma. Progressive central calcification or ossification over time and the presence of similar patchy opacities elsewhere in the lungs are clues to this metabolic deposition process.
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