CTICasesSmoking-Related Pulmonary Langerhans Cell Histiocytosis
Imaging findings
Incidental CT on a lung cancer screening scan in a 50-year-old smoker shows multiple upper-zone predominant centrilobular nodules and thin-walled cavitary lesions (cheerios) with relative sparing of the lung bases, consistent with pulmonary Langerhans cell histiocytosis.
Key takeaways
Pulmonary Langerhans cell histiocytosis (PLCH) is a smoking-related interstitial lung disease. When encountered on lung cancer screening scans, it can be classified with a 2S modifier, recognizing the characteristic upper-zone predominant nodules and cysts.
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