CTICasesDiffuse Idiopathic Pulmonary Neuroendocrine Cell Hyperplasia (DIPNECH)
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Imaging findings
CT reveals mosaic attenuation with areas of low and higher attenuation lungs, and smaller vessel diameters in low attenuation regions, indicating air trapping with a lobular distribution. Multiple centrilobular nodules are present, with several larger lung nodules (approximately 7-8mm) in the extreme lower lung bases.
Key takeaways
DIPNECH typically presents with intractable asthma-like symptoms, commonly in older females. Imaging shows air trapping due to constrictive bronchiolitis, centrilobular nodules, and sometimes larger nodules that pathologists consider carcinoid tumors. Biopsy is usually needed for definitive diagnosis, and larger nodules should be observed.
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