CTICasesMulticentric Castleman's Disease (HHV-8 Associated, Plasma Cell Type)
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Imaging findings
CT reveals multiple enlarged, enhancing lymph nodes in the axillary and inguinal regions. The pathology showed findings typical of the plasma cell variant, with plasma blasts positive for HHV-8.
Key takeaways
Multicentric Castleman's disease, especially in HIV-positive patients, is often associated with HHV-8 and typically of the plasma cell type. These lesions can show substantial enhancement and respond well to rituximab therapy, leading to resolution of lymphadenopathy.
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