CTICasesMultifocal Adenocarcinoma of the Lung
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Imaging findings
Chest CT shows a very large number of bilateral, ground-glass, part-solid, and solid nodules distributed throughout both lungs. Biopsies of multiple lesions proved various stages of the adenocarcinoma spectrum, including adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma.
Key takeaways
Multifocal lung adenocarcinoma can present with numerous synchronous ground-glass and part-solid nodules. These lesions are typically independent primary tumors with different genetic profiles rather than metastases, presenting a significant management challenge where systemic therapies, localized resections, or close surveillance must be carefully balanced.
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