CTICasesAnti-MDA5 antibody-associated dermatomyositis
Imaging findings
CT scan of a 40-year-old male with a skin rash and rapidly progressive respiratory failure requiring VV-ECMO shows diffuse interstitial opacities, dependent consolidation (DAD pattern), traction bronchiectasis, and subsequent pneumomediastinum.
Key takeaways
Anti-MDA5 dermatomyositis is characterized by amyopathic or hypomyopathic skin lesions and rapidly progressive interstitial lung disease (often manifesting as DAD or acute interstitial pneumonia). It carries a poor prognosis and requires aggressive immunosuppression.
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