CTICasesPhoto-Negative Migrating Immunotherapy-Induced Pneumonitis
Imaging findings
CT chest scans obtained only 4 days apart in a patient on immunotherapy (monoclonal antibody) show a striking 'photo-negative' pattern of rapidly migrating ground-glass opacities and consolidations, clearing in previously affected regions and appearing in previously spared zones.
Key takeaways
Immunotherapy-induced pneumonitis can present with rapidly migrating, volatile patterns of organizing pneumonia. The extreme rapidity of this geographic 'photo-negative' redistribution (occurring over days) is highly unusual and suggests a dynamic, volatile immune-mediated response.
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