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Pulmonary Tumor Embolism

Imaging findings

Chest CT in a patient with a history of parotid gland squamous cell carcinoma shows bilateral, tree-in-bud and centrilobular pulmonary nodules. The pulmonary arteries are mildly dilated, and the patient has clinical signs of pulmonary hypertension. High-resolution MIP reconstructions show the nodules are centered within the small pulmonary arterioles. Histopathology confirms widespread intravascular tumor emboli/metastases with minimal alveolar invasion.

Key takeaways

Pulmonary tumor embolism is a form of metastatic disease where tumor cells embolize and proliferate within the pulmonary microvasculature. It is a well-known cause of progressive dyspnea and subacute pre-capillary pulmonary hypertension. On CT, it can mimic infectious bronchiolitis or excipient lung disease by presenting as tree-in-bud and centrilobular nodules, and histopathological diagnosis is key.

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