CTICasesGood Syndrome
Imaging findings
The case began with a large anterior mediastinal mass, subsequently identified as a thymoma upon removal and biopsy. Over several years of follow-up, the patient experienced multiple pulmonary infections, including cavitating lesions and subsegmental opacities, primarily in the right lung, leading to scarring. CT imaging consistently demonstrated widespread and conspicuous bronchial and bronchiolar abnormalities, including wall thickening and intraluminal material, throughout multiple generations of segmental bronchi.
Key takeaways
Good syndrome is a rare paraneoplastic immune deficiency characterized by the association of a thymoma with recurrent infections due to hypogammaglobulinemia, affecting both B-cells and T-cells. Patients with thymomas should have serum immunoglobulin levels measured, as the immune deficiency and infectious complications may develop or become apparent later in the disease course.
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