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Invasive Pulmonary Mucormycosis

Imaging findings

CT in a neutropenic stem cell transplant patient shows multiple rapidly growing nodules with a dense outer rim of consolidation and a ground-glass center (reversed halo/bird's nest sign). Biopsy of the lesions confirmed invasive Mucor infection.

Key takeaways

The reversed halo sign (or bird's nest sign) in a neutropenic patient is highly suggestive of angioinvasive fungal infection, particularly mucormycosis. Early recognition is vital because Mucor requires prompt surgical debridement and specific anti-fungal therapy.

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