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Fibrotic Hypersensitivity Pneumonitis

Imaging findings

Chest radiograph shows reticulation in the peripheral lungs. High-resolution chest CT shows subpleural reticulation, predominantly in the lower lungs but also involving the upper lung zones, with ground-glass opacity in the central lung and subtle mosaic attenuation/air trapping on expiration. Surgical pathology demonstrates chronic interstitial inflammation, focal NSIP-like fibrosis, and numerous non-necrotizing granulomas with giant cells.

Key takeaways

Fibrotic hypersensitivity pneumonitis can mimic idiopathic pulmonary fibrosis (IPF/UIP) or non-specific interstitial pneumonia (NSIP) on imaging. The presence of subtle lobular air trapping on expiration, central ground glass, and the pathologic finding of interstitial granulomas or giant cells point toward chronic HP.

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