CTICasesAlpha-1 Antitrypsin Deficiency with Dendriform Pulmonary Ossification
Imaging findings
CT shows severe, panlobular emphysema with complete destruction of the lung parenchyma, particularly in the lower lobes. Associated with the emphysema is extensive, branching dendriform calcification/ossification throughout the interstitial spaces of the lower lobes.
Key takeaways
Dendriform pulmonary ossification is a rare form of diffuse heterotopic bone formation in the lung interstitium. It can be seen in patients with chronic lung disease, including severe panlobular emphysema from alpha-1 antitrypsin deficiency.
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