CTICasesAlpha-1 Antitrypsin Deficiency with Dendriform Pulmonary Ossification
[...]. Alpha-1 Antitrypsin Deficiency with Dendriform Pulmonary Ossification. CTICases. Published September 11, 2020. https://cticases.com/c/pemw5
Imaging findings
CT shows severe, panlobular emphysema with complete destruction of the lung parenchyma, particularly in the lower lobes. Associated with the emphysema is extensive, branching dendriform calcification/ossification throughout the interstitial spaces of the lower lobes.
Key takeaways
Dendriform pulmonary ossification is a rare form of diffuse heterotopic bone formation in the lung interstitium. It can be seen in patients with chronic lung disease, including severe panlobular emphysema from alpha-1 antitrypsin deficiency.
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