CTICasesLymphocytic Interstitial Pneumonia (LIP) in association with B-cell Lymphoma
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Imaging findings
Initial CT showed extensive, bulky, partially confluent mediastinal, hilar, subcarinal, and intralobar lymphadenopathy associated with B-cell lymphoma. Extensive opacification throughout the lungs with multiple thin-walled cystic lesions in a perivascular distribution, increasing in number and size towards the lung bases, consistent with LIP. Follow-up CT after treatment showed improving opacification, residual nodularity, and persistent cystic lesions with characteristic appearance. Abdominal windows showed improved lymphadenopathy post-treatment.
Key takeaways
Lymphocytic Interstitial Pneumonia (LIP) can be associated with B-cell lymphoma. The imaging findings include extensive pulmonary opacification and thin-walled cystic lesions, increasing in size and number from upper to lower lungs. Mediastinal lymphadenopathy in these cases can be bulky and lymphoma-like. Cystic spaces are common in B-cell tumors due to protein production, and while often associated with LIP, they can occur independently.
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